Donor Nephrectomy for Kidney Transplantation

Donor nephrectomy is a surgical procedure to remove a healthy kidney from a live donor for transplant into a person whose kidneys no longer function properly. In this procedure, the kidney is freed using four ports and removed through an incision in the lower abdomen.

 

A kidney transplant is a commonly adopted treatment for kidney failure as an alternative to a lifetime of dialysis. It has emerged as a popular treatment, in the wake of drastically increasing numbers of people waiting for a kidney transplant. The demand for donor kidneys far outweighs the supply of deceased-donor kidneys, which makes living-donor kidney transplant an attractive option.

 

In simple terms, it involves an implantation of a donated kidney into the lower abdomen to restore kidney function. The kidney transplant surgeon prepares the kidney and places it in the recipient. Alternatives to this procedure include observation, haemodialysis and peritoneal dialysis with poor outcomes and prognosis compared to transplant.

 

The traditional surgical technique for living-donor nephrectomy is open surgery using lumbotomy, which causes some morbidity due to the incision. The introduction of minimally invasive surgery in general practice has reduced this morbidity thus improving patient safety. Multiple studies have also shown other advantages such as less bleeding, faster postoperative recovery, less need for analgesic agents and better cosmetic results

Surgical Assessment of Donors

There are two main aspects of donors

1.    Assessment of the viability of extraction, selecting the appropriate side for the nephrectomy.

2.    Evaluation of any concomitant urological pathology that may contraindicate donation.

This assessment is made using anamnesis, careful physical examination and imaging tests.

Surgical Techniques

Open living-donor nephrectomy
Open nephrectomy can be performed through various surgical approaches (median or subcostal laparotomy, lumbotomy) and may be transperitoneal or extraperitoneal. The most commonly used technique is extraperitoneal lumbotomy and, as mentioned above, this is the reference technique with which new surgical procedures are compared.

Mini-incision living-donor nephrectomy
After the introduction of laparoscopic surgery, modifications to open surgery were developed in an attempt to compete with laparoscopic surgery. Thus, mini-incision nephrectomy was developed, which consists of performing an anterior, flank or posterior nephrectomy, with an incision of about 7cm in length. This is also considered minimally invasive surgery.

Hand-assisted laparoscopic living-donor nephrectomy
This surgical technique was developed to overcome the steep learning curve involved in pure laparoscopic surgery. The name refers to the insertion of the hand throughout the surgery process to facilitate surgical manoeuvres and provide greater safety by allowing immediate control of bleeding caused by injury to the large vessels. The incision for inserting the hand can be made at different locations, with the optional use of devices that assist in maintaining the pneumoperitoneum, according to surgeon preference.

The hand-assisted organ extraction technique is not included in this section because the incision is made at the end of the intervention and is only used for the extraction of the organ itself.

Retroperitoneoscopic living-donor nephrectomy
This technique was developed to reduce intra-abdominal handling, thus reducing complications in that area. Using this approach, the space is reduced, and the anatomical view is different from the transperitoneal, making it somewhat difficult. Possible disadvantages are the risk of pneumomediastinum, pneumothorax, pneumopericardium and gas embolism.

Robot-assisted living-donor nephrectomy
The use of robot-assisted living-donor nephrectomy, pure and hand-assisted, has been reported but experience is minimal. Using the robot’s instruments, finger movements can be performed with greater mobility than with conventional laparoscopy, although at greater cost.

Advantages and disadvantages of living donor kidney transplantation.
Kidneys from living donors have better graft and patient survival rates for the recipient than do kidneys from deceased donors. This is because living donors are physiologically and hemodynamically normal; hence, the graft is not exposed to ischemic alterations associated with brain death or cardiac death in deceased donors. Also, transplantation can be scheduled electively, with both donor and recipient surgeries coordinated at the same facility. This minimizes cold ischemia time for the donated kidney.

In ideal circumstances, kidney transplantation from a living donor is pre-emptive, so that the recipient with end-stage kidney disease (ESKD) avoids the complications of dialysis altogether. Healthy donors are exposed to some, albeit limited, medical and surgical risks, as well as some degree of postoperative pain. 

Current Trends in Donor Nephrectomy

With the advancements in technology, most of the donor nephrectomies are done Laparoscopically (keyhole surgery) with obvious advantages like:
– Fast recovery
– Less morbidity
– Less hospital stay
– Early return to work
– Better cosmetic results

Consultations for Donor

The donor chosen for the transplant must undergo a series of consultations before he/she can be deemed suitable for donating a kidney.

An expertise transplant surgeon is required for the same. The donor must undergo the investigations in the supervision of Urologist/Genitourinary Surgeon, Nephrologists, transplant coordinators, and a counsellor.

Conclusion

Living kidney donation is a procedure that is not exempt from risk. Nevertheless, extraction by laparoscopy allows us to offer donors minimal morbidity and mortality with excellent results for both the donor and recipient. The emergence of this type of surgery has increased the number of living donors by decreasing donor morbidity, which allows us to safely promote this source of organs.

Reference: https://drrahulyadav.com/donor-nephrectomy-and-kidney-renal-transplant/